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Irbesartan lowers blood pressure with minimal change in heart rate. When taken in doses up to 300 mg 1 time per day reduction in blood pressure is dose-dependent, but with further order Avapro No Prescription in the dose of the hypotensive effect of irbesartan growth is negligible. Respectively compared with placebo. The antihypertensive effect is maintained in long-term treatment. After cessation of treatment blood pressure gradually returns to the initial value, withdrawal symptoms were observed.

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Pharmacokinetics Once inside well absorbed from the gastrointestinal tract. Cmax of irbesartan in plasma achieved through 1, Order Avapro No Prescription. Irbesartan has linear pharmacokinetics and dose proportional in the dose range from 10 to 600 mg; at doses greater than 600 mg 2-fold higher than the maximum recommended dose becomes nonlinear kinetics of irbesartan decrease absorption. to cellular components of blood is insignificant. Vd — 53 — 93 orders Avapro No Prescription. When taken daily 1 times a day Css achieved within 3 days. Irbesartan biotransformed in the order Avapro No Prescription by order Avapro No Prescription and conjugation with glucuronic acid. Pharmacokinetics in special clinical situations The somewhat higher plasma concentrations of irbesartan were observed in women compared to men.

Correction doses of irbesartan in women is required. Correction doses of irbesartan in elderly patients is not required. In patients with impaired renal function or patients undergoing hemodialysis, pharmacokinetics of irbesartan are not significantly altered. Irbesatan not removed from the body during hemodialysis. Pharmacokinetic studies in patients with severe hepatic impairment have not been conducted.

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However, in some cases, especially in patients who are on hemodialysis or in patients over the age of 75 years, the starting dose should be 75 mg may use Avaproya in tablets of 75 mg. In patients with hypertension and type 2 diabetes, treatment should be started at a dose of 150 mg 1 time per day and gradually increase to 300 mg — dose, which is the preferred maintenance dose for the treatment of nephropathy. In patients with impaired renal function correct dosing regimen is required.

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In the group of patients who vascular tone and renal function is predominantly dependent on the activity of the RAAS e. As with other antihypertensive agents, a significant reduction in blood pressure in patients with coronary artery disease can lead to myocardial infarction or stroke. Treatment should be under the control of blood pressure.